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This revealed significant changes in chromatin accessibility at liver genes or regulatory sequences, including APOA1 , CYP2E1 , FGB , Fibrinogen Gamma Chain ( FGG ), and Translocase of Outer Mitochondrial Membrane 40 ( TOMM40 ) (Fig

Similar content being viewed by others Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), is characterized by an excess of lipids in the liver and components of the metabolic syndrome, such as obesity, type 2 diabetes, hypertension, and dyslipidemia [1]

Since major antioxidant protection of living systems is maintained by the antioxidant enzymes, a significant effort is being devoted to the development of therapeutic strategies centered on the design, in vitro, and clinical studies of enzyme mimetic compounds

Until recently, it was thought that cytokines, i.e