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doi: 10.1038/nature22405 207 PanRYHeLZhangJLiuXLiaoYGaoJet al

Originally discovered in human plasma, this copper-bound peptide plays a key role in tissue remodeling, collagen synthesis, and the reactivation of dormant hair follicles

The oxidized GSSG is then recycled by GSH reductase, sustaining a high intracellular GSH/GSSG ratio

The study involved 411 adult patients with T2DM and was designed as a randomized, double-blind, placebo-controlled trial where patients received varying doses of danuglipron or a placebo