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Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels

Activation of the SIRT1/Nrf2 pathway, such as by alpha lipoic acid, can modulate iron metabolism and mitigate ferroptosis by up-regulating ferritin and ferritin heavy chain 1 (FTH1), and down-regulating the iron import protein divalent metal transporter 1 (DMT1) (Zheng et al., 2023)

Apply Vaseline or Aquaphor Soothing Skin Balm to the inside of the nose at least 3 times per day and more if they are very dry