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A., Ng, F

Hypoxia increases HIF-1 protein levels while inducing vascular endothelial growth factor-A (VEGF-A) mRNA expression [101]

K.HolmgrenA.1988Thioredoxin and related proteins in procaryotes

These side effects limit the dose that can be administered, reducing drug efficiency, primarily because most anti-neoplastic agents are rapidly metabolized and eliminated from the body 3,4