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Finally, 150 L of DMSO was added to each well and the formazan absorbance was detected at 492 nm by using a multiskan

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REDEFINE 2 (Phase 3a, NEJM 2025) Davies et al., n=1,206, 68 weeks, T2D + BMI 27

Clinical Benefits & Side Effects Observations from Phase 2 human clinical trials

56 Unfortunately, functional regeneration rarely occurs in the CNS and neurogenesis is restricted to a few distinct domains, such as the subventricular zone and the dentate gyrus of the hippocampal formation