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Panobinostat structural docking analysis The PDB file of human HDAC1 was downloaded from the AlphaFold database ( and the Mol2 file of panobinostat was downloaded from the ZINC database ( AutoDock4 was applied for the docking simulation between HDAC1 and panobinostat

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Consequently, they hold tremendous potential for the treatment of various diseases

15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 Although the specific mechanisms have not been fully elucidated, the hypothesis that gut microbiota influence neurodegenerative processes through immune regulation, metabolite secretion, and nerve signaling is widely accepted