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Without adequate collagen production and remodeling, injuries to these tissues struggle to regenerate properly, often resulting in scar tissue thats weaker and less functional than the original tissue

It is also reported to be closely involved in the pathology of multiple sclerosis and other inflammatory diseases in the CNS [237]

Consistent with this hypothesis, recent studies identified various subgroups of mDA neurons through single-cell RNA-seq analysis and established that mDA neuron diversity emerges during postmitotic development