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In contrast, periodontal ligament fibroblasts are situated between the tooth root and alveolar bone, where they not only contribute to the stability of the tooth but also possess the ability to differentiate into osteoblasts and cementoblasts, thereby promoting the regeneration and remodelling of bone and cementum [90, 91]

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found that the combination of arsenic trioxide (1 M) and imatinib (0.25 M) was more effective and efficient than imatinib monotherapy in inducing apoptosis in K-562 CML cells