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Excessive ROS not only causes DNA damage and genetic instability but also affects immune metabolism pathways, weakening the immune systems normal function, thus promoting cancer development and progression as well as cellular aging and tissue function decline 96

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The clinical data also proved that the dopamine D2 receptor (DRD2) expression in recurrent glioblastoma is significantly higher than that in primary glioblastoma

The differences in iron levels between men and women are largely influenced by sex hormones, which regulate iron metabolism through a number of specific mechanisms