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Glutathione is built in two ATP-dependent steps (glutamate-cysteine ligase, then glutathione synthetase), used in redox and detox reactions, and later cleaved by gamma-glutamyl transpeptidase the only enzyme able to break its unusual gamma peptide bond

[PubMed] [Google Scholar] 18.Dharmarajan TS, Kanagala MR, Murakonda P, Lebelt AS, Norkus EP

Patients should not rush dose increases and should communicate with their prescribers if side effects are limiting their ability to maintain adequate nutrition or physical activity