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However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)

Bioaccumulation in invertebrates such as Daphnia magna and biomagnification in fish like zebrafish cause oxidative stress and reproductive toxicity at 0.1 mg/L (Wang and Liu, 2022)

doi: 10.1089/pop.2015.0003 20

Delton Family Distinguished Professor in Organic Chemistry, and Joshua Munger, professor in the Department of Biochemistry and Biophysics and an expert in cancer cell metabolismare exploring ways to refine potential drugs that could inhibit this process and improve outcomes for patients