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GABA in the glia can act as a metabolic substrate and be finally re-converted to glutamine, transferred to neurons, and converted to glutamate, which re-enters the GABA shunt

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Other conditions such as POTS (Postural Orthostatic Tachycardia Syndrome heart rate increases when standing up, often manifesting as fainting or dizziness), blood pressure changes (often related to dysautonomia issues), MCAD (Mast Cell Activation Disorder sometimes severe and unusual allergy symptoms) are commonly associated with EDS, but are not definitive for diagnosis

Because of this origin, it is studied as a potential communicator between mitochondria and the rest of the cell, a role researchers refer to as retrograde mitochondrial signaling