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It is important to note that this neurohormonal stress response has an additional endocrine leg in the form of glucagon: together, one of the important effects of this trio is to enhance the release of glucose, amino acids and fatty acids, a coordinated catabolic response to stress (186)

The activation of the PI3K and MAPK signalling pathways and the CXCL12/CXCR4 axis and the increased expression of matrix metalloproteinases (MMPs) may stimulate extracellular matrix remodelling, thereby promoting the migration of MSCs (Maeda, 2020)

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