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To elicit neuronal firing, MSNs were held at 70 mV with direct current injections in the current clamp configuration, using bridge compensation, and depolarization was provided by 5-s long current ramps of increasing magnitude (maximal current ranging from 50 to 300 pA)

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Mounjaro, which contains the same active ingredient, tirzepatide, is another prescription drug by Eli Lilly that is FDA-approved for type 2 diabetes

This mechanism may bring new molecular targets and treatment strategies for diseases with related mutations