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Nature 617 , 386394 (2023)

The synergistic benefit demonstrated by the combination of VCO and GSH NPs suggests a potential for multi-targeted therapy in ALF management

Recent statistics show that the incidence of AKI in general hospitalized patients is approximately 1015%, while it can exceed 50% in intensive care units ( In most cases, the integrity of renal parenchyma is compromised by renal tubular dysfunction caused by low perfusion or by direct damage to renal interstitial tissues and cellular functions by toxins ( This review examines the sources of oxidative stress in AKI, the mechanisms by which oxidative stress-induced ER stress contributes to cell death through autophagy and apoptosis, and discusses the potential of antioxidants to alleviate these processes in the treatment of AKI

For Image Lab analyses, band detection and background subtraction were performed automatically by the software according to the default quantification settings