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The ensuing sections will delineate the mechanisms underlying these changes

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The lipid or lipid-like particle may comprise, for example, a cationic lipid, a neutral lipid, an amino acid or peptide based lipid, a polyethylene glycol (PEG) -lipid (e.g., a lipid having a PEG chain), such as Hydrogenated Soy Phosphatidylcholine (HSPC), Cholesterol (CHE), 1, 2-distearoyl-glycerol-3-phosphoethanolamine-N- [ methoxy (PEG) -2000] (DSPE-PEG2000), 1, 2-distearoyl-sn-glycerol-3-phosphoethanolamine-N- [ methoxy (PEG) -2000 modified at the distal end of the chain with a maleimide group, 1, 2-distearoyl-sn-glycerol-3-phosphoethanolamine N- [ maleimide (PEG) -2000], DSPE-PEG2000-MAL, a polyethylene glycol (PEG) polymer, a polyethylene glycol (PEG) and a copolymer, and a copolymer comprising a copolymer, and a copolymer, 1, 2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N- [ methoxy (polyethylene glycol) -550] (DMPE-PEG550), 1, 2-dioleoyl-1-3-trimethylammonium propane (DOTAP), and those having a glycerol backbone (e.g., DMG-PEG, DSG-PEG (DMG-PEG2000)), and the like

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