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showed that individual with above-median serum MSTN concentrations had higher brachial diastolic blood pressure and higher carotid - femoral pulse velocity compared to controls ( 4.4 MSTN-mediated tissue crosstalk in diseases The expression of MSTN is not limited to skeletal muscle, it is also expressed in myocardium, adipose tissue, brain, kidney and circulating white blood cells ( 5 The inhibitor of MSTN In view of the importance of MSTN in regulating muscle homeostasis, the inhibitors targeting the MSTN signaling pathway have been developed for clinical use to improve patients with sarcopenia and muscular dystrophy

The retatrutide 12mg cohort did not demonstrate this plateau pattern within the 48-week observation window