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3) Pistachios A pistachio-supplemented diet decreased TMAO levels in 39 prediabetic subjects [59]

While human clinical trials remain limited, the preclinical evidence creates strong theoretical support for therapeutic applications

Compared with controls, the PPHN rats exhibited increased histone acetylation in the promoter region of the eNOS gene in pulmonary vascular endothelial cells, suggesting that elevated eNOS expression in PPHN is associated with histone modifications [110]