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231 HIF-1 and HIF-2 are involved in regulating angiogenesis (e.g., VEGF) to couple osteogenesis, but HIF-1 primarily influences early osteoblast differentiation and may inhibit load-induced bone formation, whereas HIF-2 has a more pronounced role in regulating bone mass under specific conditions (e.g., in mature osteoblasts) and may exhibit functional complementarity or specific target gene regulation compared to HIF-1

The normal histological features across all examined organs suggest that GO@GSH-FA does not induce cytotoxicity and is well-tolerated in the treated mice

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