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To deplete intracellular GSH, cells were treated with BSO, an inhibitor of glutamyl-cysteine ligase (GCL), the rate-limiting enzyme in de novo GSH synthesis

Glial cells that provide nutrition to the neurons and provide a link with the immune system, responding to damage by acting as scavengers of pathogens and neuronal debris, were more vulnerable than neurons to organophosphorus pesticides

Furthermore, the serum-free culture supernatant derived from EBC-1 cells transfected with siVEGF-A significantly, but not completely, suppressed tube formation (Fig

Transforming growth factor beta suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model