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These findings suggest the inclusion of NAC as an important component of comprehensive CAP control regimens [63]

Retrograde tracing of RGCs Three days before sacrifice, mice were anesthetized and fixed in a stereotaxic instrument (RWD Life Science, Shenzhen, China) using blunt ear bars

Overall, the above results show that senescent cells display high levels of ROS, increased Fe 2+ and alterations in lipid metabolism that prime them for ferroptosis, a fate prevented by GPX4 upregulation