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Nanoparticles from small- and large-scale batches were indistinguishable in core size and spectral properties, as verified by TEM and UV/Vis (Fig

In the process of physiological ageing, both systemic and tissue-specific systems show functional downfalls, which, when projected to the brain, translate into weakening defence and metabolic strain resulting from age-dependent declines of the cardio-vascular system and overall decreases in metabolism

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The tBid promotes the activation of mitochondrial outer membrane permeabilization (MOMP) effector proteins BAX and BAK, which further trigger the recruitment of other caspases to perform apoptosis [148]