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The hyperactivation of mTORC1 in cancer promotes the conditions needed for uncontrolled cell growth and proliferation, including an abundant supply of macromolecules and energy, as well as the presence of both pro-proliferative and anti-apoptotic signals

Both ROS production and scavenging are tightly regulated by specific signaling proteins within the cell ( 3 Types of ROS ROS have become integral by-products of aerobic life since the evolution of molecular O 2 in the atmosphere, primarily produced by oxygenic photosynthetic microorganisms

Key triggers include: 1

Combining different treatment modalities (including lifestyle interventions, pharmacotherapies and bariatric surgery) may support people to achieve individualised long-term goals, maximise health benefits and improve quality of life