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A novel mutation in CFAP47 causes male infertility due to multiple morphological abnormalities of the sperm flagella

These are involved in various cellular functions, including telomerase activity, DNA damage repair, cell proliferation control, cancer, immunity as well as anti-oxidative mechanisms (Wirthlin et al., 2018)

Patients with lower baseline GH typically see more pronounced early changes

Therefore, a well-established directed evolution method, using the toxic riboflavin analogue roseoflavin, can be applied to enhance riboflavin production in promising probiotic lactobacilli whilst remaining food-grade 184