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Upon re-encountering the antigen, IgE crosslinking initiates degranulation, releasing mediators such as histamine, which drive the acute manifestations of food allergy

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Excess ROS production can increase NF-kB expression in immune cells, leading to excess secretion of pro-inflammatory cytokines, including TNF-a, IL-1, IL-6, IL-8, IFN-g, iNOS, COX-2 [50]