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As traditional cigarette volumes decline in highly regulated markets, consumers increasingly seek smoke-free options perceived as less harmful, driving exponential growth of the E-cigarette and Vaping Market and heated tobacco products market

We cannot say that e-cigarettes cause cancer based on our study, but we do observe e-cigarette users exhibit some similar epigenetic changes in buccal cells as smokers, and these changes are associated with future lung cancer development in smokers

For SVMR, we also used, alternatively, Generalized single variable Summary-data based MR (GSMR) to identify and remove instruments with heterogeneous causal estimates suspected to be invalid instruments with apparent pleiotropic effects on both exposure and outcome disease (using the recommended default HEIDI (heterogeneity in dependent instruments) -outlier threshold (0.01) to retain sufficient power to detect heterogeneity) 91

Additionally, the inhalation of snuff can also lead to increased risk of nasal and sinus cancers