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39 RheeS

Figure 10 Figure 11 3.6.3 Significant differential metabolites The results are shown in Figure 12

Nevertheless, due to the compensative mechanisms of the basal ganglia, thalamic nucleus, and the cerebellum, the clinical symptoms of motor deficits do not appear until 50%70% of the dopaminergic neurons in substantial nigra are impaired and the dopamine levels in the striatum are depleted by approximately 80% (George et al., 2009