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In the first clinical study, a multicentre, randomised, double-blind, placebo-controlled, parallel-group study by De Grandis et al

Because of this lipophilicity, ALCAR can easily cross the highly restrictive blood-brain barrier, allowing it to deliver targeted metabolic support directly to energy-starved neurons and glial cells in the brain

The receptor is translocated to the nucleus upon androgen binding and ultimately results in the transcriptional regulation of a number of genes via androgen responsive elements