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Importantly, the age at onset has shifted downward, with the majority of patients developing symptoms during childhood or adolescence [6]

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

Circulating mtDAMPs activate pulmonary neutrophils and endothelial cells, causing increased vascular permeability, alveolar edema, and acute respiratory distress syndrome (ARDS)a major cause of postoperative morbidity and prolonged mechanical ventilation (96)