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Glutathione adducts & their metabolites Intracellular GSH is present in the cytosol (8590%), with the remainder being found in the mitochondria, nuclear matrix and peroxisomes Citation[82]

Several factors can lead to the uncontrolled production of ROS, including damage to the mitochondrial complex I and III, which are the major sources of ROS, reduced ATP production, or malfunctioning of enzymes such as superoxide dismutase (SOD) that convert ROS into non-toxic molecules (Elfawy and Das, 2019)