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The major regulator of autophagy is the mechanistic (also known as mammalian) target of rapamycin (mTOR) signaling, which is closely associated with the activity of mitochondria

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In peripheral tissues, they can be found in adipocytes, cardiomyocytes, and osteoblasts as they are essential for glucose-insulin homeostasis, gastrointestinal motility, cardiovascular health, inflammation, and tissue growth and repair (4)

ERO1 is likely aggregation-prone based on its structure: it contains an outer thioredoxin-like CXXCXXC motif that is catalytically active, an inner C-terminal active site near an FAD moiety, and 12 additional cysteine residues