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Polyclonal and monoclonal antibodies directed against protein-bound aldehyde adducts have been of great help in exploring the aldehyde-related modifications of the cell proteome, while mass spectrometry-based techniques have been playing a key role in elucidating the stoichiometry and sites of covalent protein modification with reactive aldehydes

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Signal 8 , 289291 (2014)

This atrophy and loss of function are often a primary cause of neuropathology, as for example is caused by substantial decreases in expression and function of glutamate transporters in Wernicke-Korsakoff encephalopathy or toxic brain damage