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Poorly controlled blood glucose increases the risk of cardiovascular disease, nephropathy, retinopathy, and neuropathy

The right form depends on the patients health needs and therapy type

Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial

While this represents a reasonable duration for clinical trials, it provides limited information about safety with years-long continuous use