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Description

Substrates of casein kinase typically require a priming phosphorylation event to catalyze phosphate addition 70,71,72

Currently, most targeted treatments in development for LRRK2-associated PD are LRRK2 kinase inhibitors, other approaches include inhibition of GTPase activity as an indirect means of controlling LRRK2 activity, and the development of LRRK2 degraders using antisense oligonucleotide and the proteolysis targeting chimeras (PROTAC) technologies [200]