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In a CCl-induced liver fibrosis model, MSCs-Exos restored autophagy function, suppressed endothelialmesenchymal transition (EMT), and modulated the expression of multiple miRNAs (such as miR-153-3p and miR-27a) through the non-canonical Nrf2/Keap1/p62 signaling pathway, thereby reducing collagen deposition, apoptosis, and inflammatory responses [136]

All concerned establishments are warned not to distribute, advertise, or sell the said violative food supplements and food product until CPR are issued, otherwise, regulatory actions and sanctions shall be strictly pursued

Joao Braga De Abreu Neto, Federal University of Rio Grande do Sul, Brazil

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