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Melatonin as an anti-oxidant in Liver disease Due to high amounts of intracellular concentrations of glutathione(GSH), superoxide dismutase (SOD), catalase, and lipid soluble antioxidants [40], hepatocytes are stable to injuries caused by Reactive Oxygen species (ROS) and Reactive nitrogen species (RNS)

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8.1.3 Policy integration recommendations Cross-sectoral coordination mechanisms: Establish standing committees or task forces bringing together representatives from health, agriculture, environment, commerce, and labor ministries, charged with: Harmonizing food safety standards with environmental quality standards and occupational exposure limits Coordinating surveillance and monitoring programs to share data and analytical capacity Jointly developing public education campaigns addressing multiple risk dimensions Aligning enforcement mechanisms and penalty structures across sectors Integrated risk assessment frameworks: Adopt exposure assessment methodologies that characterize total carcinogenic burden from all pathways (dietary, environmental, occupational) rather than evaluating sources in isolation

Cell Microbiol (2003) 5(9):64960