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The compound's ability to restore tissue homeostasis and reverse age-related functional decline in animal models provides direct evidence for the role of senescent cells in aging processes, while its applications in cancer research offer insights into senescence mechanisms in disease progression and administration resistance

Controlling the manufacture of telomerase, an enzyme that helps maintain and elongate telomeresthe protective caps on the ends of chromosomesis the aim of Epithalon, which was developed to mimic the effects of Epithalamin

In a transected Achilles tendon model in rats, the Sikiric group reported dose-dependent improvement in functional recovery, biomechanical strength, and histological healing markers compared with saline-treated controls [Sikiric et al., Inflammopharmacology, 2018]

15,18 These epigenetic alterations lead to metabolic dysregulation, cartilage degradation, and joint dysfunction (Figure 1)