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In fact, worsening asthma control and exacerbations are consistently linked to lower lung GSH levels and higher oxidative potential (35, 36)

This augmented protein breakdown helps in preventing the buildup of harmful protein aggregates

AlphaFold3-predicted 3D structural modeling suggested that KW substitutions alter both the binding affinity and interaction pattern between HMGB1/2 and Importin Alpha 5 (IMA5, a key nuclear import mediator for HMGB1/2) (Figure S5A-B)