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As a result, drawing precise conclusions about complex processes, such as fat oxidation, lipid metabolism, and overall energy balance, becomes a significant challenge in controlled research settings

Conceptually however, EAE presupposes that MS is also driven by a primary autoimmune attack originating in the periphery, and if this assumption proves incorrect, then this model may be fundamentally misleading with respect to the true etiology of MS

Its also worth noting that individuals may experience different symptoms or levels of improvement from B12 injections, depending on their health status and B12 levels before injection

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