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Therefore, maintaining healthy levels of SAMe and glutathione is crucial for optimal liver function and effective detoxification

Mitochondrial ROS production and oxidative mtDNA damage is increased during reoxygenation in the GPX1 knockout mice, in addition to structural abnormalities in cardiac mitochondria and myocytes, suggesting GPX1 may play an important role in protecting cardiac mitochondria from reoxygenation damage in vivo

So, when we say glutathione is reduced, we mean it can remove oxygen or ROS hence its being an "antioxidant" after which the glutathione becomes oxidized

discovered a new mitochondrial quality control mode called mitocytosis, in which abnormal mitochondria are released into the extracellular space through migrasomes [73]