48 LiuM.KongX
2022;9(32):e2203106
Be accredited as in this article by the apparent metabolism transformation of MIM/ agent, (for example, on mRNA or protein level, raised or reduce) gene that CoQ10 regulates is a medicine target of the present invention.Medicine target of the present invention includes but not limited to list in subsequently the gene among the table 1-28 (for example, table 2-4 and 6-28) among this paper.Based on the result of experiment of describing by the applicant among this paper, receive vital protein that Q10 regulates and comprise transcription factor, apoptosis reaction, pentose phosphate pathway, biosynthesis pathway, oxidative stress (prooxidant), membrane change and the metabolic different approaches of oxidative phosphorylation or group of molecules is relevant or can be by different approaches or the group of molecules of classifying.Based on the combination that provides among this paper, the vital protein that following general introduction is regulated by CoQ10.Receive that CoQ10 regulates and for the vital protein of transcription factor be HNF4 .Receive the CoQ10 regulation and control and comprise Bcl-xl, Bcl-xl, Bcl-xS, BNIP-2, Bcl-2, Birc6, Bcl-2-L11 (Bim), XIAP, BRAF, Bax, c-Jun, Bmf, PUMA and cMyc with the relevant vital protein of apoptosis reaction.Receiving CoQ10 regulation and control and the vital protein relevant with pentose phosphate pathway is transaldolase 1.Receive CoQ10 regulation and control and the vital protein relevant to comprise COQ1, COQ3, COQ6, prenyltransferase and 4-hydroxybenzoate with biosynthesis pathway.Receive CoQ10 regulation and control and the vital protein relevant to comprise neutrophilic granulocyte kytoplasm factor 2, nitricoxide synthase 2A and superoxide dismutase 2 (mitochondrion) with oxidative stress (prooxidant).Receive CoQ10 regulation and control and the vital protein relevant to comprise cytochrome c, complex 1, composite I I, composite I II and composite I V with the oxidative phosphorylation metabolism.Other vital protein that directly or indirectly regulated and control by CoQ10 comprise Foxo 3a, DJ-1, IDH-1, Cpt1C, cam kinase II
In comparison to the TCCG motif, CCCGCCCG and CGGGAT showed moderate levels of methylation
