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The Journal of neuroscience: The official journal of the Society for

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Both conditions feature elevated prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) via Cyclooxygenase-1 (COX-1)/Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) activation, respectively, which amplify neuroinflammation (microglial activation) and synovial inflammation (fibroblast activation) (200, 302)