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11 , 567578, doi:10.1038/nrm2944 (2010)

all_toxicology_topics Topics in Toxicology Acetaminophen Toxicology Drug Names: Tylenol and others Source: Analgesic & Antipyretic Mechanism of Action: Acetaminophen is rapidly absorbed from the stomach and small intestine and metabolized by conjugation in the liver to nontoxic agents, which then are eliminated in the urine In acute overdose or when maximum daily dose is exceeded over a prolonged period, the normal pathways of metabolism become saturated Excess acetaminophen is then metabolized in the liver via the mixed function oxidase P450 system to a toxic metabolite Under conditions of excessive

In addition to energy metabolism, astrocytes contribute to GABAergic signaling by synthesizing GABA through the MAO-B and diamine oxidase pathways, and possibly through glutamate decarboxylation [299302]