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Several studies have proved the clinical efficacy of Doxil, where improved tumor response rates and a favorable safety profile were observed compared to the conventional formulation of doxorubicin

Stress stimuli and altered cellular metabolism might trigger an increase in ROS production and a depletion of antioxidant defense systems, resulting in a defective mitochondrial respiratory chain, mutation in mtDNA, and altered Ca 2+ homeostasis

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J Proteome Res 15:31083117 Leonard MM, Bai Y, Serena G, Nickerson KP, Camhi S, Sturgeon C, Yan S, Fiorentino MR, Katz A, Nath B et al (2019) RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis