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That's an interesting point re the decrease of levo and taking 12 weeks to leave the body ..I'm thinking that timing would match when they reduced from 75mg to 50 mg and why she got so poorly over a 3 month period ..some real pearls of wisdom BB001 ..enlightening ..thank you She might not need 100mcg .might need something in between 75mcg and 100mcg Many people have to fine tune levothyroxine dose Small dose adjustment after getting to 75mcg Perhaps 75mcg 4 days a week and 87.5mcg 3 days Always the same brand levothyroxine at each prescription (making sure she takes levothyroxine EVERYDAY and on empty stomach and no other medications within 2 hours..and PPI at least 4 hours awayrecommend a weekly pill dispenser.especially if she ends up needing to fine tuning dose) But

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FEBS Lett 596, 12411251.Google Scholar Intili, G, Paladino, L, Rappa, F et al