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These include positive regulators, such as ferredoxin 1 (FDX1) , lipoic acid synthase (LIAS) , lipotransferase 1 (LIPT1) , dihydrolipoamide dehydrogenase (DLD) , thiolipoamide S-acetyltransferase (DLAT) , pyruvate dehydrogenase E1 subunit 1 (PDHA1) , and pyruvate dehydrogenase E1 subunit (PDHB) , as well as negative regulators, like metal-responsive transcription factor-1 (MTF1) , glutaminase (GLS) , and cyclin-dependent kinase inhibitor 2 A (CDKN2A) [25]

Considering that global temperature continues to increase and there is an urgent need for the development of adaptation strategies to maintain agricultural yields, a better understanding of the influences of the high temperature on plant physiology and growth is required

Insulin resistance, a hallmark feature of metabolic syndrome and NAFLD, is another critical target modulated by polyphenols

These findings highlight the importance of EAAT2 localization and trafficking for normal synaptic function, and provide a theoretical basis for novel pathophysiological mechanisms in neuropsychiatric diseases