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While preliminary evidence supports the involvement of the ferroptosisHMGB1 axis in VAF progression, further experimental validation is warranted ( 3.4.2 Cardiac diseases 3.4.2.1 Drug-induced cardiomyopathy Drug-induced cardiomyopathy, particularly caused by chemotherapeutic agents such as doxorubicin (DOX) and sorafenib, remains a serious complication of cancer therapy and is closely associated with ferroptosis and HMGB1-mediated inflammation (Zhang et al., 2021)

[ 244 ] The epithelialmesenchymal transition (EMT) serves as a determining factor in triggering cancer metastasis by suppressing epithelial gene activity and elevating mesenchymal gene activity, thereby amplifying the migratory and invasive capabilities of tumor cells

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