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Periodic measurement of vitamin B 12 levels for individuals undergoing metformin treatment, especially if they display symptoms like anemia or PN, is integral to this integrated approach aiming to optimize metformins benefits while mitigating potential risks associated with vitamin B 12 deficiency, ensuring comprehensive patient care in the context of diabetes prevention and management [7, 46]

However, their efficacy in vivo models has not been reported yet

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One twin remained more severely ill than the other, but both children were discharged after 3 weeks without sequelae