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From an inflammatory perspective, in contrast to other regulated cell deaths, such as necroptosis and pyroptosis, which are highly immunogenic and induce inflammation [41] the influence of ferroptosis on immune system remains a subject of debate

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Astrocytes are star-shaped glial cells critical for neuronal support, ionic homeostasis, neuroprotection, and synaptic regulation [127]

Also the mechanism of substrate-induced D2 degradation is strongly or completely impaired by replacement of Sec by Cys or Ala, respectively (88), suggesting that modification of this Sec residue during catalysis may be an essential step in the inactivation of the enzyme