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Clinical trials predominantly document mild and self-limiting adverse effects such as abdominal distension, lower limb hypoesthesia, and transient pain exacerbation, which typically resolve without necessitating extensive medical intervention [4, 21, 25, 26, 66]

The risk of bias in the included studies was assessed using the Cochrane Collaboration's tool for randomized controlled trials and the Newcastle-Ottawa Scale for observational studies

doi: 10.3389/fphar.2021.627533 Goldstein, A

The transferrin ligand itself, along with engineered peptides such as the T7 peptide (HAIYPRH), has demonstrated strong affinity for TfR